The Value Of Spiral CT Perfusion Imaging In The Differential Diagnosis Of Pulmonary Nodule (or Mass)

PURPOSETo evaluate the clinical efficacy of spiral CT perfusion combined dynamic contrast—enhanced CT imaging in differential diagnosis of pulmonary nodule (or mass) .MATERIALS AND METHODSEighty-one patients (57 men, 32 women, age range, 25—82 years, mean age, 54 years) with pathologically or clinically diagnosed pulmonary nodule (or mass) underwent perfusion CT scan and dynamic contrast—enhanced CT scan. All the cases were divided into malignant group (49 cases), benign group (21 cases) and active inflammatory group (11 cases). All perfusion image data were transferred into body perfusion-2 software for creating and analyzing perfusion images and parameters which including Blood Flow (BF), Blood volume (BV), Mean Transmit Time (MTT) and Permeability Surface (PS). The enhanced value (EV) of nodule (or mass) and ratio of mass-to-aorta peak enhancement (PEm/PEa ×100%, RATIO) were calculated, the characteristics of time-density curve( TDC) of the three groups nodule (or mass) were studied. The results of the enhanced value (EV), ratio of mass-to-aorta peak enhancement (PEm/PEa × 100%, RATIO) and the four perfusion parameters among the three groups were analyzed by simple factor analysis, and P <0.05 were considered statistically significant.RESULTSAmong the three groups, the mean BV and PS of malignant and active inflammatory nodule (or mass) were significantly higher than that of benign group (BV: P = 0. 012 and 0.038, PS: P =0.002 and 0.000). The mean BF and MTT among...