| OBJECTIVE To investigate the effects of atorvastatin (ATV) on the blood pressure, cardiac function, serum cholesterol level in spontaneously hypertensive rats (SHR). METHODS Male 8-week-old SHR were divded into 2 groups and given distilled water (SHR, n=6), or 50mg/kg (ATV, n=6) of ATV daily, by gavage, for 10 weeks. Wistar-Kyoto rats (WKY, n=6) were used as normotensive control. The systolic blood pressure (BP) were measured using the tail-cuff method and the left-ventricular (LV) function, including the indexes of dystolic interventricular septum depth (IVSd), dystolic left-ventricular inner-diameter (LVIDd), dystolic left-ventricular posterior wall depth (LVPWd), fraction shortening (FS%) and ejection fraction (EF), were assessed by echocardiography. The arterial hemodynamic parameters, carotidartery pressure (CAP), mean intra-ventricular pressre (IVP), left ventricular peak pressure(LVPP), and ±dp/dtmax, as well as the concentrations of serum total cholesterol (TC) level, HDL-C and LDL-C, were determined after the treatment. RESULTS The systolic BP of ATV was reduced (180.3±5.93 vs. 199.6±11.5mmHg in SHR, P<0.01). Compared with SHR, CAP and IVP (P<0.05) were lower in ATV additionally with the higher absolute values of ±dp/dtmax (P<0.01). IVSd, AP, and IVP all decreased (P<0.05), while FS% and EF increased (P<0.01) in ATV. The levels of TG LDL-C (P<0.05) and TC (P<0.01) in ATV were lowered compared with SHR, however, the HDL-C was no significant difference. CONCULSION Atorvastatin can reduce sytolic blood pressure and serum TC, partly improve the LV function in SHR. |
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