The Expression Of Osteopontin And Matrix Metalloproteinase-2 In Early Pregnant Chorion And Hydatidiform Moles

Objective:1.To profile the changes in osteopontin and marix metalloproteinase-2 expression in normal placentas.2.To profile the changes in osteopontin and matrix metalloproteinase-2 expression in hydatidiform mole.3.To profile the relativity of osteopontin and matrix metalloproteinase-2 expression in normal placentas and hydatidiform moles.Method:Expression of osteopontin and matrix metalloproteinase-2 were detected in 40 normal placentas ,15 cases with hydatidiform moles by immunohistochemistry technique.Result:The expression of osteopontin and matrix metalloproteinase-2 in early chorion was observed in trophoblasts cells. Osteopontin secretion increased gradually in early chorion from 6 to 9-12 wk. However, MMP-2 production declined from Week 6 to Week 9-12.But there were significantly positive correlations between osteopontin and matrix metalloproteinase-2 at Week 6.In hydatidiform moles,the expression of osteopontion was lowly,and the expression of matrix metalloproteinase-2 was highly, There were significantly negative correlations between osteopontin and matrix metalloproteinase-2 in hydatidiform moles.Conclusion:1.Our findings suggest osteopontin may play important roles in the placentation.2.The down-regulation of OPN in hydatidiform moles may play a role in the pathogenesis of hydatidiform mole.3.MMP-2 may play important roles in the early period of the placentation.4.The upregulation of MMP-2 may be one of the pathologies of the hydatidiform moles.5.Both osteopontin and MMP-2 may promote the early period of the placentation.6.There were significantly negative correlations between OPNand MMP-2 in hydatidiform moles,so we suggest there were different pathogenies in them.