Effects Of Genetic And Environmental Risk Factors To Esophageal Cancer In Huaian Population

Esophageal cancer is one of the most deadly cancers in China and the mortality rate of esophageal cancer ranks the fourth. According to the present studies, the esophageal cancer is known as the polygene hereditary disease, and the environmental factors play a very important role. Therefore, it is important to study the genetic susceptibility and environmental risk factors and the gene-environment interaction on esophageal cancer, in high-incidence areas for definitude of pathogenesis of esophageal cancer and prevent formulation of scheme.The principal results of this paper are as follows:1. A case-control study on the environmental risk factors to esophageal cancerA case-control study was performed in which 206 controls were matched to 206 original esophageal cancer cases by gender, ethnicity, and age (±5 years). Controls are defined no disease history of cancer and digestive system. Logistic regression model was applied to screen possible environmental risk factors. The results show the environment risk factors related with esophageal cancer were smoking, hobby of hot food, drinking water and family history of digestive tumor. Population Attributable Risk of the four factors was 1.3%, 52.0%, 54.3% and 40.7%, respectively. Drinking tap water was a protective factor, but drinking well water was related with esophageal cancer (OR=3.327, 95%CI=1.208~9.166).2. The distribution of ns-cSNPs and mRNA-UTR SNPs of NQO1 gene in Han population in HuaianNonsynonymous cSNPs and mRNA-UTR SNPs of Quinone Oxidoreductase1 gene were detected by Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...