Relationship Between High Density Lipoprotein Antioxidant Activity And Carotid Arterial Intima-media Thickness In Essential Hypertension Patients

Objective:To compare the differences of high density lipoprotein(HDL) antioxidant activity, the susceptibility of HDL to oxidation, the lipid peroxidation degree of HDL and the paraoxonase activity between normal people and the essential hypertension patients.To explore the factors that may affect the antioxidant capacity of HDL. To study the correlations between antioxidant activity of HDL and the carotid artery IMT(intima-media thickness) in the essential hypertension patients. Methods: 33 patients with essential hypertension and 32 normal people with matching age and sex were included. HDL and LDL were isolated by one step density grandient ultracentrifugation, and induced oxidation with external Cu²⁺. Antioxidant activity of HDL, lag time,lipid peroxidation degree were determined by spectrophotometric and TBARS methods. We measure the activity of paraoxonase (PON) in serum with continuous monitoring using phenylacetate as substrate. We use the ultrasound...