| Objective Analyze the relevance between the MCP-1 levels and its pathological changes in the blood serum and urine of the Han nationality SLE patients in Yunnan Province.Methodology To analyze and compare MCP-1 levels in the blood serum and urine between 25 Yunnan Han nationality SLE patients and 9 healthy persons with ELISA: The data was analyzed with statistics method. Results ①the MCP-1 levels in the blood serum and urine of all SLE patients and non-renal failure or renal failure SLE patients were remarkably higher than that of healthy group (t=2.855,3.260 ; 2. 885, 3. 447; 3. 235, 2. 999. p=0. 008, 0. 004; 0. 009, 0. 003; 0. 004, 0. 007). ② The MCP-1 levels in the urine of the renal failure SLE patients was much higher than that of non- renal failure SLE patients (p=0. 001) ; The MCP-1 levels in the blood serum of non- renal failure SLE patients and renal failure SLE patients did not show much difference (t=-1. 754, p=0. 093) . ③The MCP-1 levels in the blood serum of the SLE patients decreased dramatically after 2-week treatment (t=2. 725, p=0. 034) ;The MCP-1 levels in the urine of those treated patients showed signs of dropping, but it wasn' t difference before and after the treatment vary much (t=2. 353, p=0. 057). ④ The MCP-1 levels in the blood serum and in the urine of the SLE patients showed positive correlation and also were proportional to the marks of SLEDAI (r=0. 930, P=0. 000) , 24-hour protein definite quantity of the urine(r=0. 483, P=0. 014) , mouth ulcer (r=0. 458, P=0. 021) and pleurisy (r=0. 464, P=0. 020) but indicated negative correlation with hemoglobin (r=-0. 536, P=0. 006) . ⑤ The MCP-1 levels in the urine of SLE patients was positive correlation with the 24-hour protein definite... |
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