Effects Of Hepatocyte Growth Factor On Cell Apoptosis And Proliferation In Disused Muscular Atrophy

Background:Limb fixation is the main treating method to joint injury, disused muscular atrophy caused by it has profound effects to the outcome and recovery of function. Once disused muscular atrophy happens, it will be a long period to recover and has negative effects to muscular strength, function and daily life, even severer than illness per se in certain condition. In modern society, trauma caused by traffic and other accidents increases exponentially, and severe trauma increases year after year. Disused muscular atrophy has been a common factor to affect the recovery and bring sequelae. It is an important task to find a novel way in preventing and treating disused muscular atrophy.Now treatment to disused muscular atrophy mainly lies in kinetic treatment, physic treatment and drug treatment. However, limb fixation is necessary in severe tissue trauma, it is unsuitable to use kinetic and physic treatment, which will aggravate illness; drug treatment can affect skeletal muscle in different mechanism, yet it has little effect because lack of specificity to muscular growth. In our study, regeneration of skeletal muscle is the focus, mainly lies in satellite cells of skeletal muscle. In 1971 Moss and Leblond proved increasing of muscular nucleus is caused...