Effects Of Hepatocyte Growth Factor On Contract Function Of Disused Gastrocnemius Atrophy In Rats

BACKGROUND Disused atrophy of skeletal muscle is one of the common complications in clinical practice. Fixation, arrestment and imponderability is the most common cause of atrophy. However, Fixation and arrestment is one of the most important methods in clinical therapy of bone and joint disease. Many treatment options of internal diseases need the patient long term lying in bed. All of them had taken atrophy which could have a strong impact on the therapy and rehabilitation of diseased limbs. Some of them even have more effects than the disease itself. With the development of society and Modern Medicine, how to cure and reducing the complication is one of the most important subject. The most direct performance of skeletal muscle atrophy is not only quality and contract function decreased, but also the increase of cell apoptosis and the injury of cells. In present, the mean method of atrophy therapy is physiotherapy. The study of drug therapy is weak.Hepatocyte Growth Factor is a kind of multifunctional cell factor which was found by professor Nakamura in 1984. It play important roles in the regulation of cell functions including stimulating proliferation and migration, enhancing survival of various cell types. In present, a lot of studies prove that HGF could improve axon...