Expression And Its Clinic Significance Of STAT3 And STAT5 In The Epstein-Barr Virus Associated Nasal NK/T Cell Lymphoma

【Objective】To study the expressions of STAT3 and STAT5 and its role in the development of Epstein-Barr virus(EBV) associated nasal NK/T cell lymphoma which is a rare disease. To analysis the relationship between the expressions of STAT3 and STAT5 and the clinicopathologic characteristics of the nasal NK/T cell lymphoma to benefit the diagnosis ,treatment and prognosis of this disease.【Method】25 cases of EBV associated nasal NK/T cell lymphoma and its clinical data were collected. The expressions of STAT3, STAT5, LMP1, Survivin and Ki67 were detected with immunohistochemical method. The expression of EBER1/2 was detected with in-situ hybridization method. The expressions of STAT3 and STAT5 and the expressions of LMP1, Survivin, Ki67 were correlated. The relationship of the expressions of STAT3 and STAT5 with the clinicopathologic characteristics of the tumor was analyzed. The prognostic value of STAT3 and STAT5 was also studied. Tissues from 20 cases of chronic sinusitis were as the control group.【Results】The positive rates of EBER1/2 and LMP1 in 25 cases of nasal NK/T cell lymphoma were 92.0% and 60.0%, respectively. The positive rates of STAT3 in the lymphoma and in the chronic sinusitis were 56.0% and 10.0%, respectively. The difference was significant, p<0.01. The positive rates of STAT5 in the lymphoma and in the chronic sinusitis were 68.0% and 15.0%, respectively. The difference was significant, p<0.01. The expression of LMP1 was positively related to that of STAT3 and STAT5 (r=0.428, p<0.05 and r=0.490, p<0.05). The expression of STAT3 was positively related to that of Survivin and Ki67 (r=0.428,p<0.05和r=0.704,p<0.01).The expression of STAT5 was not related to that of Survivin and Ki67.The...