Expression Of COX-2 In Hypopharyngeal Carcinoma And Its Clinical Significance

ObjectiveHypopharyngeal carcinoma is a common malignant tumor in head and neck , invasion and metastasis are responsible for the high death rate. Recently studies indicate that cyclooxygenase-2 (COX-2) is up-regulated in many kinds of malignancies . The aim of this research is to investigate the expression of cyclooxygenase-2(COX-2) in hypopharyngeal carcinoma tissues and to study on the relationship between the expression of cyclooxygenase-2 (COX-2) and clinical pathological characters in hypopharyngeal carcinoma by immuno-histochemical method.MethodsThe expression of cyclooxygenase-2(COX-2) in hypopharyngeal carcinoma tissues of 40 cases and paraneoplastic hypopharyngeal normal mucosa of 15 cases was studied by immunohistochemical method, and to study the relationship between the expression of cyclooxygenase-2(COX-2) and clinical pathological characters.ResultsThe positive rate of cyclooxygenase-2(COX-2) expression in hypopharyngeal carcinoma tissues(67. 5 %) was significantly higher than...