The Effect Of Acidic Neuropeptide On Expressions Of NGF, Aβ, NMDAR1 And MGluR2, 3 In Brain Of AD Rat

Background and PurposeAlzheimer's disease(AD), characterized clinically by progressive loss of memory and cognition, pathologically by senile plaques(SP), neurofibrillary tangles(NFT), and synapse loss, is an age-related neurodegenerative disorder. The primary pathogeny and cause of AD remains unknown. The morbidity of AD is high among the elderly. In developed countries ,AD has already been the fourth leading cause of death after heart disease, cancer and stroke for lack of effective early diagnostic and therapeutic methods. So it is very important and urgent to actively study AD.The nucleus basalis of Meynert(nbM) locates in the base of the forebrain. Almost all of neurons in nbM are cholinergic neuron. Neurofibers sending out from nbM spine into hippocampus, cerebral cortex and other brain regions. Ibotenic acid (IBO) is a kind of NMDA receptor agonist with strong excitatory neurotoxin. It can damage the learning and memorial ability of the rat eternally and steadily. The ideal animal model can be made by injecting IBO into the nbM of the rat.Neuropeptides are some important substances which have functions of neuronal signal transmission and regulation. They distribute widely in the central nervous system, and participate in many kinds of functional regulation. An Yuhui has isolated some small neuropeptides from animal brains and found a new peptide,acidic neuropeptide (AP). It is a small molecular peptide, and has not antigenicity. Animal...