The Expression Of EGFR And HER-2/neu And Its Relationship With Prognosis In Gastric Cancer

Background:Gastric cancer is the common malignant tumor with a risk to human health. Diffusion and metastasis is the important cause of cancer-related deaths. In China, at least 160 000 people died of gastric cancer, with the highest death rate for all cancer. Though obvious improvement has been achieved in diagnostic and therapeutic research of gastric cancer, most of gastric cancer patients were diagnosed as advanced stage. The treatment of appeasable surgery and chemoradiotherapy did not significantly improve survival time of advanced gastric cancer patients. It is a key task for cancer research to search novel prognostic marker, improve early diagnostic rate, and new target of molecular targeted therapy of gastric cancer. Objective:1. To investigate expression of EGFR and HER-2/neu in 103 cases of gastric adenocarcinoma and 20 cases of normal gastric tissue, and discuss the relationship between EGFR and HER-2/neu expression between in gastric cancer and normal gastric tissue.2. To discuss the relationship between EGFR and HER-2/neu expression and various clinicopathologic parameters of gastric cancer, and to increase sensitivity and...