Organic Combination Of Matrine And Dexamethasone And Authentication

Leukemia, a kind of malignant tumors, is seriously harmful to health of mankind, especially to children. At the past century, great progress had achieved in the treatment of tumor due to the development of researches and clinical practice. Surgical operation, radiotherapy and chemotherapy have become the usual approaches for tumor treatment. Then traditional chemotherapy and bone marrow transplantation have mainly adopted to leukemia treatment, but gave unsatisfied curative effect,and serious toxic reaction or limited inclications. It is urgent to explore some other effective approaches of leukemia treatment, such as antiblastic, differentiation inducter, metastasia inhibitor, therapeutic sensitizer, gene therapy and stem cell transplantation.Matrine, an extract componet from traditional Chinese medicin Sophora flavescens Ait has studied as a differentiation inducter of leukemia for many years. But it's molecular function mechanism is still unclear due to the interaction target with matrine in leukemia cell is unexplored up to now.