Expression And Clinical Significance Of Muti-Drug Resistance Factors: P-gp,GST-Ï€,TOPOÏ€ In Lung Cancer

Objective To examine the expression of P-gp,GST-π,TOPOПand Ki67 in lung cancer and study on clinical relationship between P-gp,GST-π,TOPOП,Ki67 Co-expression in lung cancer.Method The expression of P-gp,GST-π,TOPOПin 52 cases of lung cancer was detected by immuno-histo-chemical staning.Results①the positive rates of P-gp,GST-π,TOPOП,ki67 were 73%,80.5%,62.5%,23.7%.The P-gp,GST-πexpression were correlated with the histology and differentiation , The expression of TOPOПwas higher in adenocarcinoma than in other histologys;②the individual expression rate of P-gp,GST-π,TOPOПwas 3.5%,0,12.5% ;the co-expression rate of P-gp and GST-πwas 35% ; the co-expression rate of P-gp and TOPOПwas 3.5% ;the co-expression rate of GST-πand TOPOПwas 14% ; the co-expression rate of P-gp,GST-πand TOPOПwas 30% ; The co-expression rate of more than one MDR gene was 84%,which was apparently more than individual expression rate (16%).(P〈0.05)③The expression Ki67 was correlated with the differentiation of the lung cancer.Conclusion P-gp,GST-π,TOPOПcan express in d ifferent types of lung cancers,with different expression levels,and correlate with multidrug resistance of lung cancer, Ki67 was the marker of the...