The Study On The Relationship Between Polymorphisms Of Homocysteine Metabolism Related Enzymes And Ischemic Cerebrovascular Disease

CVD, which has high incidence, mortality, and disability, is a common and dangerous disease and now has become one of three most fatal diseases. Among them, ICVD is up to 80%. The etiology of ICVD is complicated and not understood completely until now. New researchs has discovered that ICVD is related with both hereditary and environmental factors.Recently, many researchers focus on the predisposing genes of the related risk factors of cerebral infarction. HHcy is a new important and independent risk factor to atheroscleorosis and cerebral infarction. Therefore, the metabolism- relative enzyme of Hcy has become one of candidate genes. But the correlation between these gens and ICVD is still uncertain.In order to further investigate the correlation between the metabolism-relative gene polymorphism andlCVD, the research detected the MTHFR, CBS and MS genes by PCR-RFLP in a large sample and observed the distribution of genotypic frequency and allel frequency amongHan people in Henan province in China.Up to now ,treatment methords of ischemic cerebrovascular disease (ICVD) are still poor .Therefore ,to prevent occurrence of ICVD, especially to prevent and intervene the risk factors for ICVD are very important. The study on the risk for...