Differentiation Of Bone Mesenchymal Stem Cells Into Neuron-like Cells By The Filum Terminale.

Objective:Stem cell strategies is the main stream of life science these years, its basic research and appliance must break the neck of disease treatment and become the mainstay of bioproduction in the 21 century. Neural stem cells, defined by Reynols 1992, which were derived from the adult mice corpus striatum firstly, can uninterruptly proliferate and multidifferentiate in vitro and in vivo. NSCs not only can be the model for researching the development of neural system and source of potential seed-cells, but provide a new way to treat the nervous system diseases. Scientists have made many animal model for the nervous system diseases' treatment and provided a lot of theories for degenerative, congenital and injury diseases in nervous system. But how to get enough seed-cells and avoid the controversy in ethics and clinical application is the big problem. Recently, some reports have demonstrated that bone mesenchymal stem cells (BMSCs) can be differentiated into neuron-like cells in vivo and in vitro under appropriate conditions and significantly improved the cognitive functions of the animals and human, indicating that BMSCs may be a promising...