Expression Of P33～(ING1b), P53 And Ki67 In Transitional Cell Carcinoma Of Bladder

[Background and objective]Tumor suppressor gene negatively control cell growth. Inactivation of its normal functions may cause tumorigenesis.Up to now, the best known and maybe the most important of all tumor suppressor genes is P53, which is altered in about half of all human tumors, making it the most frequent target for genetic alterations in cancer. According to Garkavtsev's report, P53 does not restrain cancer single-handedly and seems to require an co-stimulatory factor-a novel candidate tumor suppressor, P33^ING1b has been implicated in the negative regulation of cell proliferation and in thecontrol of apoptosis and cellular aging. Conversely, if production of P33^ING1b is down-regulated or suppressed by using antisense mRNA, cells can escape from P53-mediated growth inhibition.Expression of P33^ING1b was closely physically related with P53 protein. P33^ING1b protein may be a member of the family of P53 protein. it is regards that there is an interrelation between P33^ING1b protein and P53 protein. But there are also reports that there is not interrelation between them in some respects. Analysis of the interrelation between P33^ING1b and P53 plays an important role in understandly of the occurrence and development of the transitional cell carcinoma of bladder. Ki67 protein is a kind of nuclear proteins related to the cell proliferation. It is...