The Effects Of Behavior Training On The Proliferation And Migration Of Neural Stem Cells In The Dentate Gyrus In Rats After Hippocampal Infarction

Cerebral ischemia, as a common disease of the central nervous system (CNS), seriously harms people's health with impairment of motor, sensory perception, especially the impairment of the ability of learning and memory, which is the most common and lasts a long time. Large amounts of experiments shows that decease of neuron after ischemia is the reason of impairment. Since Reynolds found the existence of neural stem cells in the striatum of adult rats in 1992,multipotent neural stem cells have been found to persist throughout life in various mammalian species including humans,and continuous neurogenesis from those cells has been detected in adults.It has been shows that various insults including cerebral ischemia stimulate the endogenous neural stem cells proliferation either in known neurogenic site or in regions where neurigenesis normally does not occur.After proliferation,the neural stem cells migrated to the injured regions and differentiated to the neuron which is the important foundation of the plasticity of brain and make it impossible to treat cerebral ischemia with NSCs.In CNS,however,the amounts of endogenous NSCs is not enough to repair...