The Effect Of Shenlingbaizhusan On The Mouse Originated Splenasthenic Diarrhea Of Immune Function

Objective: To investigate the effect on allieving diarrhea and immual system in treatment of diarrhea due to hypofunction of the spleen in rat model,and reveal the mechanism between declination of immnologic function and diarrhea.Methods: The SLBZS has been applied to diarrhea of rat model sufferred from spleen deficiency after taking Rhubarb The variation of index in rats has been observed ,such as: ingestion spontaneous activity,stool frequently,shape and properties,spleen/thymus gland weight, RBC-C₃b -RR, RBC-IC-R and the rate of carbon powder propused,the phagocytosis of macrophage,the serum amylase and D-xyloseResults: compared with model,each index is p<0.01 posses obviously statistical significance. 1 .The SLBZS could consideraly alleviate diarrhea and retain losing weight;2. The SLBZS could promote RBC-C₃b -RR and RBC-IC-R effectly compared with Dioctahedral smectite,P<0.01;3. The SLBZS could promote the spleen/thymus gland weight index of rats compared with Dioctahedral smectite,P<0.01;4.The SLBZS could inhibit the rate of carbon powder propused compared with Dioctahedral smectite,P<0.01;5.The SLBZS could promote the phagocytosis of macrophage compared with Dioctahedral smectite,P<0.01;6.The SLBZS could promote the content of serum amylase and D-xylose in serum evidently, compared with Dioctahedral smectite,P<0.01.Conclusion: The SLBZS and Dioctahedral smectite could considerably alleviate diarrhea and gain weight;The SLBZS promote the spleen/thymus gland weight index of rats and RBC-C₃b-RR and RBC-IC-R;The SLBZS inhibit the rate of carbon powder propusied;The SLBZS promote the phagocytosis of macrophage;The SLBZS promote the conten of serum amylase and D-xylose;The SLBZS pathological observation proced it could protect and recover the gastrointestinal mucosa.