The Study Of The Effect Of Specific Immunotherapy On The Serum Levels Of IL-18 And IL-10 In Chronic Urticaria Patients

Objective: Chronic uticaria is a common allergic disease of dermatology, characteristic by reoccurring itching and wheal. But its' pathogenesis remain unclear. Recent studies showed that functional disorders of T helper lymphocyte subpopulation have close relationship with allergic diseases helper lymphocyte is divided into two functional subgroup,Th1and Th2.Th1 secrete IFN-γ,IL-18,IL-2 and other cytokine ,mainly participates cellular immune.Th2 secret IL-4,IL-5,IL-6,IL-10,IL-13 and other cytokine ,mainly takes part in humeral immune. Th1 and Th2 can inhibit each other and maintain dynamic balance in human body. Th1 and Th2 polarization is the key path of the immune response, Th1 and Th2 polarization disorder and defect can lead to disease. Some studies found that there was low expression of IFN-γand high expression of IL-4 in chronic urticaria patients, suggesting that there is misbalance of T helper lymphocyte subpopulation in chronic urticaria. IL-18 is a newly found cytokine secreted by Th1, which can induce Th1 differentiation and inhibit B cell secreting IgE along with IL-12. It can also improve T cell growing. IL-10 is mainly synthesis and secreted by Th2. its main function is inhibiting Th1 growing...