The Expression And Significance Of ET-1,6-keto-PGF_1a, VWF In Bleomycin-induced Lung Fibrosis Of Rat

Objective: Idiopathic pulmonary fibrosis(IPF) is a distinct and specific form of pathology performance for usual interstitial pneumonia(UIP) in idiopathic interstitial pneumonia(IIP), is the most common kind in IIP, accounts for 47%-71%. It is characterized by fibroblast proliferation and extracellular matrix (ECM) accumulation, its principal pathologic characteristics include alveolar epithelial cell, vascular endothelial cell and basal membrane damages, inflammation with neutrophils, macrophages, and lymphocytes, followed by proliferation of type II pneumocytes and fibroblasts, and collagen deposition. At present the IPF disease incidence rate and the case fatality rate assume the trend of escalation, its most common cause of death is respiratory failure, others also include the heart failure, coronary atherosclerotic heart disease, pulmonary infection and pulmonary embolism et al. But its accurate pathogenesis is still not clear, the pathogenesis was considered that the early pathology change is the lung damage, the later period is the lung fibrosis, but during the inflammation and fibrosis process in IPF, participates, the multitudinous cell factors and biological mediums, the endothelial cell has gradually received much more attentions. This article is for the purpose of discussing the rat...