Restoration Of The Appearance And Function Of Nasal Mucosa Before And After Endoscopic Sinus Surgery

Objective: To study morphologic functional mucosal change preoperatively and postoperatively in stage Ⅱ chronic sinusitis and nasal polyps (CSNP) treated with endoscopic sinus surgery (ESS). Method: ①The morphological character of nasal mucosa before and after ESS was surveyed continuously with endoscopy in 30 cases with stage Ⅱ CSNP. ② Saccharin test of nasal mucosa was taken preoperatively and six months after surgery in these 30 cases and in 26 nomal subjects as control. ③ Scanning electron microscopy was performed to exam the nasal mucosa in ten cases before surgery, three months and six months after surgery. Results: ①There were77% of nasal and sinuous cavity brought to stage of complete epithelization three month after surgery and 97% of that brought to stage of complete epithelization six months after surgery. ② Mucociliary transport rate of patients was (3.94±1.76/min) on average before surgery,which was significantly different from the one of healthy controls (8.11 ± 1.83mm/min) (P<0.01). Mucociliary transport rate for six months after surgery (7.17±2.20mm/min) was singinficantly different from the one before surgery (P<0.01), but there no significant difference between mucociliary transport rate for six months after surgery and that of healthy control (P>0.05). (3) Under electron microscopy, the nomal structure of nasal mucosa in patients with CSNP was impaired and almost completely recovered at six months postoperatively. Conclusions: The structure of nasal mucosa was damaged seriously and mucociliary transport rate decreased significantly in patients with CSNP, the impaired stucture of mucous membrane and mucociliary transport rate were greatly...