The Study Of The Relationship Between Intrauterine Growth Retardation And Leptin In Cord Blood And NO Levels In Pregnant Serum

Objective Intrauterine growth restriction (IUGR) is one of these factors to effect the quality of birth population. Because the reason of IUGR is complex, there are no effective ways to prevent and cure it. Currently, as the leptin would affect fetal growth and the role of NO in intimate relationships is not clear manner and, therefore, Leptin, NO and fetal birth weight made a preliminary study with a view of both prevention and treatment of IUGR to provide new theoretical basis.Methods: According to diagnosis criteria, we had chosen 30 cases of IUGR, 35 cases of macrosomia, 38 cases of normal groupe. Pregnant's serume and cord blood was colleted after fetal birth. Pregnants serum NO was determined by Nitric acid reaction;leptin in cord blood was measured by radio-immunoassay.Results: The NO (14.25 ± 3. 84umol/L) level in pregnant women serume in IUGR was found obviously decerased compared with the normal (32.58 ± 18. 82umol/L) (t=2.791, P<0.01) and macrosomiu group (33.23 ± 15. 3umol/L) (t=2.913,P<0.01);The cord blood leptin in IUGR (5.72 ± 2. 92ug/L) was foundobviously decreased compared with normal(8.09 ±5. 08ug/L)(t=2.894,P<0.01) and macrosomia group (8.63 + 4. 47ug/L) (t=3.130, P<0.01).In IUGR, there was no significant differences (t=1.783, P>0. 05) between the boy's cord leptin (5.41 +3. 03 ug/l)and the girl's leptin(6. 03 + 2. 81 ug/1);In normal group, there was no significant differences(t=1.692, P>0. 05) between the boy's cord leptin (8.40 +4. 97ug/l) and the girl's leptin(7. 77 + 5. 19 ug/l);In macrosomiu group, there was no significant differences(t=1.556, P>0. 05) between the boy's cord leptin (8.94 + 4. 36ug/l)and the girl's leptin(8. 32 + 4. 58 ug/1) .In IUGR, the cord blood leptin was not correlated with serum NO level (pearson correlation 0.308,P>0.05) ?Conclusion: Leptin was associated with fetal weight obviously, so both leptin and one occurrence of nitrogen oxides in IUGR would play a role. Leptin in fetal was not correlated with NO in pregnant. The boy and girl leptin levels without obvious differences.