| Objective: To study the correlations between different levels of cognitive impairment in Hyperhomocysteinemia, relevant factors-deficient (folacin, VitB12) and subcortical ischaemic vascular diseases. And explore new pathogenic factors for VCI.Methods: 119 cases of SIVD in the endoneural department were chosen for the study according to their vascular cognitive function levels. The cases were divided into two groups according to their MMSE scores: 54 cases (33 males and 21 females) in the dementia group and 65 cases (36 males and 29 females) in the non-dementia group. The average age of the two groups were (69.57 + 5.25) and (68.20±4.42) respectively. HPLC and chemi luminescence method were applied to detect their Hcy level and serum folacin and VitB12 level respectively. Comparative study was made on their biochemical indexes like blood lipid and blood sugar. Result:1. Serum Hcy level of the dementia group (43. 13 ± 9. 42μmol/L) was significantly higher than that of the non-dementia group (20. 25± 6. 25μmol/L), it proved to be with statistic significance (P<0.01).2. Serum folacin and VitB12 levels of the dementia group (3. 51 ± 1. 86ng/mL, 393.06 ± 208.63pg/mL) was significantly lower than that of the non-dementia group (5.86+1.38 ng/mL, 682.64 ± 190.95 pg/mL), itproved to be with statistic significance (P<0. 01).3. Spearman correlation method indicated that Hey of different genders was negatively correlated with MMSE scores and positively correlated with ages.4. Single-factor analysis indicted that Hey level was significantly negatively correlated with serum folacin and VitBIA but had no significant correlation with diabetes, blood lipid, hypertension, smoking and alcohol intake (P>0.05).Conclusion: SIVD cognitive impairment is proved to be aggravating with the increase of serum Hey level. Therefore, Hey might be an individual risk factor of SIVD cognitive impairment. Folacin and VitB,2 deficiency is proved to be an important nutrition factor that might cause Hey and lead to VCI. |
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