The Clinical Study Of Ambulatory Blood Pressure In Patients Of Elderly Hypertension With Cerebrovascular Disease

Objective: To observe the characteristic of ambulatory blood pressure of patients with elderly hypertension with cerebrovascular disease. Methods: 74 elderly hypertension with cerebrovascular disease and 77 simple hypertension were undergone 24h ambulatory blood pressure monitoring. Results: 24hSBP, 24hDBP, dSBP, nSBP, nDBP difference in 2 groups(P<0.05). 24h blood pressure variability did not differ between the two groups. The circadian rhythm in 70% of the patients with hypertension with cerebrovascular disease while that in 41% of the patients with simple hypertension disappears (P<0.05). Morning surge arose in 81% of the patients of hypertension with cerebrovascular disease compared with 42% of the patients with simple hypertension(P< 0.05). Conclusion: blood pressure especially systolic blood pressure has direct connection with cerebrovascular disease. The changes of circadian rhythm and morning surge are closely related to hypertension with cerebrovascular disease in elderly hypertensive patients. Morning surge increases obviously and circadian rhythm significantly disappears in patients with hypertension with cerebrovasculur disease. Recovery circadian rhythm and reduction of the morning surge could thus be a new therapeutic target for preventing target organ damage and subsequent cardiovascular events in elderly hypertensive patients.