Multilateral Analysis Of Intrauterine Infection Of Hepatitis B Virus

Background and ObjectiveHepatitis B(HB), the legal B contagious disease, has the character of complicated spreading way. Parts of hepatitis B patients will develop chronic carriers, and even to cirrhosis and original liver cancer. It is a serious public health problem. About 1/2 population of 600 million on the earth live in high spreading area of hepatitis B virus (HBV), about 200 million people were proved HBV infected, 30~40 million of among them were clinical infected, 25%~40% of which will be dead for cirrhosis or liver cancer. World Health Organization (WHO) reported that 750 thousand death cases owe to HBV. Our country belongs to the high and middle spreading area, where most of cases happened during the perinatal period and childhood. Transmission patterns includeintrauterine infection, mother milk feeding, living engage closely and little father heredity.In the past, it was believed that there was a low rate of intrauterine infection. But recent standpoint was said that the situation were more serious. For this reason, to control intrauterine infection will prevent the rage of HB effectually. In order to achieve the aim, we investigate the serum of HBV carrier mothers and later of their infants.Materials and Methods1. MaterialsHBV carrier mothers and later their infants. 57 mothers and their 57 infants were followed for 9 — 18 months. Their serum was investigated.2. MethodsHBVM was measured by ECL methods. HBV-DNA was detected byQ-PCR.3. Statistical analysisAll the data were analyzed using SPSS 10.0 Statistical analysis software. Student's x2'test was used to analysis differences between infected group and control group.Results1. 8 of 57 newborn infants were observed infected, the rate of infection was 14.04%.2. Comparing with peripheral venous blood sample, the sensitivity and positive predictive value of HBV detected in cords was 100.00%, 80.00%respectively.3. 9-—-18 months later, 14 of the infants became HBV chronic carriers.4. The fetal infectious rate in mothers with HBeAg or HBV-DNA positive was 86.67%, 100.00%, respectively which was significantly higher than that in mothers with HBeAg or HBV-DNA negative. PO.01.Conclusions1. HBeAg or HBV-DNA positive in mothers is one of the risk factors of intrauterine infection.2. HBeAg or HBV-DNA negative mothers are also infectious.3. Detection of HBV-DNA in cord blood is a sensitive index for diagnosing fetal infection , however detection of peripheral venous blood is with the significance of making correct diagnosis.