| Objective: To observe changes of hemodynamics and effects of blood preserve technique and adrenergic agonists on maintaining stable hemodynamics during orthotopic liver transplantation (OLT) without veno-venous bypass. Methods: 8 patients with severe hepatism were performed OLT by general anesthesia without veno-venous bypass. 1:1 Dopamine and furosemide (1 10.0μg·kg-1·min-1) was given during perioperation. Adrenaline or phenylephrine (50100μg) were given by intravenous bolus as soon as blood reperfusion in neohepatic stages. Blood cell saver was used in neohepatic stages . According urine output, we gave furosemide 2040mg by bolus to make urine output greater than 50100ml/h .Changes of hemodynamics and blood routin in each period were analysised. Results: Values of arterial pressure in neohepatic stages are less than those of preoperation (P<0.05) . Changes of arterial pressure in other periods were no significant difference (P>0.05).Changes of hemodynamics in ahepatic stages were mainly compensated by increase of heart rate and reduction of CVP (P<0.05) . Values of Hct and Hb after operation were greater than those of preoperation (P<0.05) . Conclusion: Hemodynamic stability was maintained during OLTwithout veno-venous bypass in the practice. Infusing fluid and blood with using blood preserve technique and adrenergic agonists reasonably, which not only avoided blood volume overload, but also maintained hemodynamic stability without veno- venous bypass.
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