The Study Of MR Perfusion Imaging In The Diagnosis Of Brain Lesions

Objective To determine the utility of MR perfusion imaging in the diagnosis of brain lesions and to evaluate the potential of relative cerebral blood volume( rCBV) in preoperative assessment of histologic grading. Methods Totally 53 cases were studied including glioma (n=23), metastases(n=12), meningioma(n=4), enpendymoma(n=l), hemangioblastoma(n=4), carvernous hemangioma(n=3), brain inflammation (n=4), radioation necrosis(n=2). Conventional MR and perfusion weighted imagings were performed in all patients. Using normal white matter in the contralateral hemisphere as a reference, the rCBV was calculated for each lesion. Results The rCBV in high grade gliomas(n=13) varied from 1.77 to 35.70,with a mean of 9.38±6.52,and in the low-grade group(n=10) varied from 1.17 to 4.33, with a mean of 2.41 ±1.24. This difference in rCBV was statistically significant. High perfusion areas were found in hemangioblastoma, glioma, metastases, meningioma. Low- and iso-perfusion was seen in the inflammation and radiation necrosis. The highest rCBV was seen in hemangioblastoma. Conclusion MR perfusion imaging can show the hemodynamic changes of brain lesions. It's useful in the assessment of histologic grade of gliomas.