Comparision Of Curative Effect On Treatment Of Severe Acute Pancreatitis With Stilamin And Sandostatin

Severe acute pancreatitis (SAP) is acute pancreatits with local complication of organ dysfunction or necrosis, abscess or false cyst ,or both of them .It is a severe and rapidly fatal disease of digestive systerm. SAP is the characteristic of complex pathogeny, state of illness changing rapidly, bad prognosis, systemic complication and mortality being high. Although the pathogeny and initiating pathophysiological processes are not known, the disease is thought to result from destruction of the pancreas and peripancreatic fatty tissue by digestive enzymes which are produced in the acinar cells and activated intracellularly or extracellularly. The damnification of pancreas stimulates neutrophil leucobyte, mononuclear lercotyte and endotheliocyte releasing inflammatory media and cell factor, and promotes a systemic inflammatory response syndrome (SIRS) taken place. This is due to necrotizing pancreatic tissue and hemorrhage and shock, ARDS and MODS taken place. Inhibiting exocrine pancreatic secretion and controlling inflammation is a rational therapeutic approach in human acute pancreatitis. At present , medicine synthetical treatment obtains curative effect preferably. Therefore the study focus is that exploring the new medicine inhibits exocrine pancreatic secretion and controls inflammation presently. Withsomatostatin(SST) occurred , the therapy of SAP has made progress rapidly. Stilamin has better curative effect.In order to observe the curative effect of Stilamin and compare with with Sandostatin. From January 1999 to February 2005, totally 45 cases of severe acute pancreatitis patients were enrollde .Patients were allocated into Stilamin treatment group 23 cases and Sandostatin control group 22 cases. The treatment group received traditional therapy in combination with stilamin, 6mg , 24 hours intravenous continuous, while the clinical symptoms alleviated, changed 3mg ,24 hours intravenous continuous. The control group received traditional therapy in combination with sandostatin 0.6mg , 24 hours intravenous continuous, while the clinical symptoms alleviated, changed 3mg ,24 hours intravenous continuous. Record the duration of hospital stay, the incidence of complications, curative rate, mortality, the days for serum amylase restoration and the duration of improvement of main symptoms . Result: stilamin could reduced the occurrence of complications, decrease the mortality and shorten the duration of hospital stay, days for serum amylase restoration and duration of improvement of main symptoms. Conclusive: stilamin comparison with sandostatin is the better effective drugs for treating patients with SAP. Discussion: the mechanism of SST treating SAP and the difference of curative effect between stilamin and sandostatin. Somatostatin...