The Role Of Interleukin-6 And Insulin Resistance In The Development Of Macrovascular Disease In Diabetes

Objective:To investigate the roles of interlukin-6, insulin resistance indiabetes mellitus with/without macrovascular disease. Methods:48 type 2 diabetes 31 nodiabetetic macrovascular disease and 14normal controls were involved in the study .IL-6 was measured byradioimmunoassy and insulin resistance (Ins-R) value was assessed byhomeostasis mode assessment (Homa).serum IL-6 ,blood lipoid were alsomeasured in fasting state . the correlation between IL-6 and Ins-R;blood lipidwere determined by multiple linear regression analysis. Results:â‘  serum IL-6 and insulin resistance are significantly higher indiabetes than in controls (p<0.01) .but both of them don't differ between innondiabetes and diabetes macrovasular group . â‘¡ in diabetes group , the insulin resistance correlates positively withserum IL-6 leverls and BMI ,LDL, TC, SBP. â‘¢ in discriminant analysis ,IL-6, Ins-R, BMI,LDL ,SBP may servesas cliscriminating marks in favour of diabetic macrovasular. Conclusion: â‘  the plasma levels of IL-6 may be as sensitive marks forearly diagnosis of diabetic macrovasular disease and predicting the prgnosis. â‘¡ plasma IL-6 maybe relate to insulin resistance in type 2 diabetes . â‘¢ routinely measure the plasma levels of IL-6 in type 2 diabetes can helpto prevent and to intervene the developing of diabetic cardiovascular disease .