The Study Of The Quality Standard Of Xiaokechuan Tablets

Manshanhong (Rhododendron dauricum L) is a traditional Chinese medicine,its leaves have the function of relieving cough,dispelling the phlegm and suppressing asthma.It has notable effect on acute and chronic bronchitis.Xiaokechuan tablets is the extraction of total flavonoids and manshanhong essential oil which is from the leaves of manshanhong.It was reported that the total flavonoids and manshanhong essential oil had obvious efficiency on relieving cough,dispelling the phlegm and suppressing asthma. In the article, the preparation and quality standard of xiaokechuan tablets have been studied.The study of extraction of manshanhong essential oil and total flavonoids is: In the article Orthogonal test was used to optimize the extract method, the result of determination of the total flavonoids and manshanhong essential oil showed that the content of total flavonoids from extraction was 5%.The preparation of xiaokechuan tablets is:To develop the suitable prescription and the method of preparation, the preparing process for xiaokechuan tablets was investigated.The Tablets prepared by using the method meet Chinese pharmacopoeia(edition 2000) regulation in all the customary.The identification of xiaokechuan tablets is:Using hyperoideis as a reference with thin-layer chromatography .The method of identification of xiaokechuan tablets was established.The determination of hyperoside is: In xiaokechuan tablets A HPLC method was established to determine the content of hyperoside is in xiaokechuan tablets. The column was C18 and mobile phase was methanol :water(45:55),the linear in the range of 0.12~1.92μg and the correlation coefficient was 0.9999.The regressive equation was Y=3063698e-07x+0.004322,the mean recovery was 100.56%.The contents of hyperoside is in five batches of xiaokechuan tablets were determined by HPLC.Rutoside being used as control ,the optimum condition for determination of the UV ,on the basis of which the total flavonoids in five batches of xiaokechuan tablets were detected by using the method.