Clinical Study On Treatment Of Chronic Heart Failure Of Qi Deficiency-blood Type By Jianxin Granule

Objective: To observe efficacy and adverse effects of Jianxin granule in treating Chronic Congestive Heart Failure (CHF) of qi deficiency-blood stasis type on clinical symptoms , sign, TCM syndrome, left ventricular function and volume(LVEF, LVESV, LVEDV), the changes of plasma levels of B-type natriuretic peptides (BNP), and changes of NYHA class and taking chemical medicines (ACEI, Hydrofiumethiazid and /or Digoxin) as the control, to objectively evaluate the efficacy and safety of Jianxin granule in treating chronic congestive heart failure.Methods: Sixty patients with chronic congestive heart failure of qi deficiency-blood stasis type entered the study and were randomized to treatment and control groups, 30 case in each. The treatment group was given Jianxin granule, six-gram one time and three times each day. The control was given captopril 12.5mg-25mg bid-tid, Hydrofiumethiazid 12.5-25mg bid, and/or Digoxin 0.125mg qd; the treatment duration was four weeks. The doppler echocardiography (LVEF, LVESV, LVEDV) , the conditions of blood, urine, excrement, liver, renal function, electrolyte and plasma levels of B-type natriuretic peptides were determined at the beginning and the end of the trail respectively. We observed the changes of clinical symptoms, sign, TCM syndrome and NYHA class, the adverse effects were illustrated in words.Results: There was very significant efficacy on treatment and control groups in treating chronic congestive heart failure of qi deficiency-blood stasis type (p<0.05). They were equivalent efficacy and had no significant difference (p>0.05). Two groups had obvious effecton TCM syndrome, sign, clinical symptoms, NYHA class, left ventricular function(LVEF, LVESV, LVEDV), and plasma levels of BNP. The NYHA class, left ventricular function were improved significantly, and TCM syndrome too. The plasma levels of BNP was decreased significantly in two groups, there was no significant difference of adverse reaction between the two groups. No significant changes of liver function, renal function ,electrolyte, blood, urine, excrement routine test were found in both groups. The side effect of cough was relatively more often in control group.Conclusions: Jianxin granule had significant treating effects in CHF of syndrome of qi deficiency-blood stasis type. Jianxin granule is a safe and effective drug of Chinese herbal medicine for CHF.