Pharmacology Effect Study Of Toutongning

Now days,in our country ,with the enhance of people's living standard, and the living rhythm become fast, the living press also strengthen . So people who had headache become more and more . The major is adult who are 25-55.And now ,the drugs which ease headache are too many ,but major come from the west. The west drugs' price often high ,and also have many negative effects, while some Chinese traditional medicines have undefmate effect.In so many Chinese traditional medicines which remedy headache, Lignsticum chuanxiong rhizome and Angelica dahuriana are advocated most . They are all belongs to umbellate. Pharmacology experiences indicate: Lignsticum chuanxiong rhizome can expand small artery, increase microartery's diameter , improve blood's rheology and microcircle . Angelica dahuriana can expand artery, accelerate blood's flow, improve blood's quality, ease pain et. These years they are extensively used in headache.The toutongning guttate pill is composed of Lignsticum chuanxiong rhizome and Angelica dahuriana root, it is made by new technique .we make use of their function of ease pain ,expand and active blood ,to make the new preparation by their available component in account of traditional principle of heal headache. This experiment is to study the four major effects of remedy headache . 1 the effect of toutongning on ease painWe stimulate the animal by four kind of method: chemistry, electricity, hot and machanic. Consequence indicate that ,the middle dose can obviously decrease the time of mice's twist by HAC. Show that middle dose have obviously effect of ease pain. The high and low doses can also ease pain by electricity .Toutongning can enhance the rate of ease pain of machanic .The high dose reach peak after tow hours. Say that the high dose have obvious effect. 2 the effect of toutongning on blood's rheologhThe model group and blank group have obviously distinct, the length wettest weight ,dry weight of thrombus obviously increase .The toutongning group can obviously reduce the length of thrombus compared to model group ,the weight of thrombus is also diminish. Show that toutongning can restrain the form of thrombus.The model group can reduce the cruor's time ,compared to the blank group, and they have obvious distinct. The toutongning group can obviously prolong the cruor.'s time compared to the model group. It is say that toutongning can obviously prolong the time of cruor.The model group have more serous adhibit than the blank group, and have obviously distinct, The high dose group can reduce the adhibit, the middle dose can reduce the adhibit of whole blood, and have obviously distinct, compared to the model group.3 the effect of toutongning on meningeal microcircleTo test the relationship of headache and microcircle, we observe the meningeal microcircle of alive rat .The consequence indicate: toutongning can accelerate the blood stream of rat, and increase the diameter, and have obviously distinct compared to the blank group. Show that toutongning can accelerate the blood stream ,expand the diameter of blood, it has the effect of improving meningeal microcircle. 4 the effect of toutongning cooperated with sodium pentobarbital on sleepToutongning can obviously prolong the sleeping latent period of mice by using sodium pentobarbital and have obviously distinct compared with blank group.The high , low dose can prolong the time of sleep. Toutongning cooperated with sodium pentobarbital, the high, middle dose have obviously distinct with the blank group, and low dose has the most distinct .Indicate that toutongning can prolong the sleeping time, increase the numbers of mice which inject the sodium pentobarbital.From above we can draw the conclusion: toutongning has the effects (1)ease pain (2) restrain the form of thrombus, reduce the adhibit of blood (3)accelerate blood stream, expand diameter of microblood, improve microcircle (4)cooperated with sodium pentobarbital can increase the sleeping time.