| Acute pancreatitis AP is a kind of common acute abdomen in surgery. the gentle type is easy to be treated,but the serious type is dangerous. it's fatality rate is high, it is also one of the most troublesome problems of acute abdomen in surgery. the main etiological factor is a inflammation caused by digestion of activated pancreas digestive enzyme to itself and Organs around it. it is also called self-digested. Bile reflu is the main factor activating pancreas digestive enzyme, getting rid of the obstruction in vater ampulla and loosening sphincter in oddis are the key to treat the acute pancreatitis because pancreatic duct and pancreatic duct all open to the vater ampulla before they enter to the lower portion of duodenum. Severe acute pancreatitis SAP is a clinicalcommon dangerous emergency with high fatality rate; with a long time continous exploring in medical science, the therapy strategy to SAP has changed from routine operation to individualized treatment program mainly in program which emerged recently. Increasing the success rate of conservative treatment of the SAP cases and decreasingit's Complicationsrates mostly depends on support and the disposal of the affected medicines. Anisodamineis theblocker of the cholinoceptor,which has the functions of relaxing smooth musclerelieve the Blood vessel spasm and ameliorating microcirculation,relieving ache,refraining Pancreatic secretion,decreasing activation of Pancreatic proenzyme,but the routine But ill effect of muscle injection with routine dose invovling paralysis of intestine and dry mouth. will happen. So using it to treat Acute pancreatitis is discussible in clinic,however recent years it was known that vein injection Anisodamine with a big dose 1.5~2.0mg/(kg.d), which is used to treat Acute pancreatitis with a little ill effect such as paralysis of intestine and dry mouth. but can relieve the microcirculatory injury, shorten the process of Acute pancreatitislower the mortality rate. Pathogenesis; nosogenesis of the SAP involves many factors, for example, self- digestion of the Pancreas organ caused by the Pancreatin. blood circulatory disorder of Pancreas and change in the permeability of blood capillary. role of the oxygen-derived free radidicals. ang endotoxin, etc. study shows that activity of phospholipase A2 will increase in blood in Acute pancreatitis patients, and the releas of phospholipase A2 speed the releas of the arachidonic acid, which can produce quantities TX A2 with the roles of the thromboxane synthase, it can make vessels fierce contract and platelet aggregate to form microthrombus. which results in the decrea sing of instillation in the Acute pancreatitis patients, finally make the Edematous Pancreas change to be SAP. on the other hand, there is endotoxemia in the earlier period of SAP, endotoxin can stimulate body release overdose inflammation Medium such as cytokine and so on., and form waterfall linkage enlargement effect which cause severe injuryof histocytey, it leads to multiple organ failure. it has been proved that inflammation Medium endotoxin phospholipase A2 amylase correlate to the pathology Alteration of the pancreas. liver. kidney ang heart and so on. This experiment result show that the level of the blood amylase PLA2 and endotoxin is obviously higher than the control group (P<0.05), at the same time, histology study show that important organs such as pancreas liver lung kidney etc are destructed seriously. but the level of therapy group the blood amylase PLA2 and endotoxin is nearer to the control group (P>0.05) injury degree of the pancreas liver lung kidney is also obviously lower, it show that SAP can induce the great increasing of inflammation Medium and positive correlate to the severity degree of the injury in abdominal cavity organs, and the Anisodamine van refrain the super-expression of inflammation Medium in SAP patients, ang relieve the injury degree of abdominal cavity organs. vein injection Anisodamine with a big dose can decrease the Exocrin... |
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