An Observation Of The Relation Of Level Of Angâ…¡ And PAI-1 With Severity Of Coronary Artery Lesions

Objective: To observation whether there is a relationship between the actual severity of CAD and the plasma concentration of AngⅡand PAI-1, and investigate the role of AngⅡand PAI-1 in the development of coronary artery disease(CAD).Method: In patients with established coronary heart disease and normal controls by coronary angiography, plasma AngⅡin aorta(AO) were measured by radioimmunoassay and PAI-1 in aorta(AO) by enzyme-linked immunosorbent assay(ELISA). The relationship of the severity of coronary lesions to plasma AngⅡand PAI-1, the relationship of plasma AngⅡto PAI-1 were assessed. Results: ⑴ The plasma AngⅡand PAI-1 levels in AO were 47.03±13.96 to 36.58±4.73,26.42±8.09 to 18.99±6.42,There were a significantly higher levels in CAD group than those of normal control group (all P＜0.05).⑵ The plasma AngⅡand PAI-1 levels in CAD group had positive correlation with the degree of coronary artery lesions in term of involved vessels(P＜0.05～0.01). The plasma AngⅡand PAI-1 levels were 38.31±11.19,20.73±6.56；47.03±13.96,23.79±2.96；52.08±7.29,34.75±14.75,respectively. ⑶.The plasma PAI-1 level was positively correlated with AngⅡ(P＜0.05).Conclude:The plasma AngⅡand PAI-1levels were significantly elevated in patient with CAD, and the plasma AngⅡ and PAI-1 level had positive correlation with the degree of coronary artery lesions. The plasma PAI-1 level was positively correlated with AngⅡ. Our findings may implicate that the interaction of fibrinolytic system and the rennin-angiotensin system(RAS) may facilitate the development of CAD.