| Background: Improved cardiovascular stability, superior metabolic control, remove inflammatory substance during continuous renal replacement therapy(CRRT) in comparison to intermittent hemodialysis (IHD),but it may be more costly than IHD. In a prospective, comparative, clinical study, we investigated whether daytime continuous renal replacement therapy that is cheaper than CRRT, is superior to IHD in critically ill patients.Methods: Thirty seven critically ill patients were divided into two groups of patients, daytime continuous renal replacement therapy (n=17) and IHD(n=20)group. Patients characteristics on baseline were not different in term of severity of illness. We analyzed parameter during therapy, such as blood pressure, heart rate, dosage of dopamine, serum creatinine and urea nitrogen, and mortality rate and survival time.Results: In contrast to daytime continuous renal replacement therapy, IHD caused a increase in heart rate(8 11 vs. -1 + 7, P<0.05)and decrease in systolic blood pressure(-13 30 vs. -2+11, P<0.05)after 1 hour; Daytime daytime continuous renal replacement therapy can decreased dosage of dopamine (5.8 9.8 vs. 17.5 5.6, P<0.05 ) duringtherapy; And the decreasing of temperature in daytime continuous renal replacement therapy was more significant than in IHD(-0.7 2.8 vs. 0.1 0.5, p<0.05) after therapy; Rebounding of serum creatinine was more significant in IHD than in daytime continuous renal replacement therapy (62+73 vs. 22 + 52, P<0.05) ; The mortality of daytime continuous renal replacement therapy and IHD were 58 percent and 75 percent respectively.Conclusion. In contrast to IHD, improved blood pressure stability and decreased heart rate, superior serum creatinine and urea nitrogen control, superior temperature control during daytime continuous renal replacement therapy in critically ill patients. Daytime continuous renal replacement therapy maybe decrease in-hospital mortality rate.
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