Relationship Between Binder Point And Prognosis Of Sever Acute Pancreatitis

Background: Severe acute pancreatitis (SAP), as a common acute abdomen, is characterized by complicated causes, lots of morbidities, difficulties in the treatment, and high mortality. The natural course of SAP progresses in three phases. The first 14 days are characterized by systemic inflammatory response syndrome resulted from the release of inflammatory mediators. In patients with SAP, organ failure is common and often occurs in the absence of infection. The second phase, beginning approximately 2 weeks after the onset of the disease, is dominated by sepsis-related complications resulted from infection of pancreatic necrosis. This is associated with multiple systemic complications, such as pulmonary, renal, and cardiovascular failure. 2 or 3-month after the onset of the disease, it enters into the third phase. Because of bad drainage, patients have rudimental cavity of peritoneum, and with pancreas leakage, intestines leakage, bile duct leakage.Despite considerable improvements in understanding of the pathophysiologic mechanisms and management of these patients, mortality of SAP remains between 20%-30%. Not SAP itself but the complications of SAP are the death reason ofpatients with SAP. In 1994 Binder M made the "Organic functional or diabetic complications of SAP and its evaluation standard", which contains two part: organic functional complications and diabetic complications.Objective: To study the relationship between Binder point and prognosis of severe acute pancreatits (SAP). Methods: 59 patients with SAP treated in our hospital between Nov 1997 and Dec 2003 have been analyzed to reveal the relationship between Binder point and complications.Result: Of the 59 patients, 49(83.1%) were cured and 10(16.9%) died. Ninety-three percent patients had complication. The difference of mortality between the group above-7-point and below-7-point is significant (P<0.001).Conclusion: Binder point is correlated to the prognosis of SAP.