The Effect Of Cordyceps Polysaccharides On Experimental Liver Injury And Its Mechanism

The assay used the chemical and immunological experimental liver injury models to investigate the effect of cordyceps polysaccharides from cordyceps gunni var minor nov in Anhui provice on liver injury on the level of cell and body respectively. It also analysed the mechanism of its protective effect on immunological hepatic injury. The main results as follows:1. Effect of cordyceps polysaccharides on CCl4-induced chemical liver injury models.Cordyceps polysaccharides( 150, 250s 500 mg kg-1, ig ) could significantly reduce elevated ALT, AST activities in plasma and MDA content of liver homogenates,and enhaced activity of SOD in liver in CCl4(1OO mg kg-1 , ip)-induced chemical liver injury mice. The pathology resul ts of liver also showed cordyceps polysaccharides had liver protection to a certain extent. All of these suggested cordyceps polysaccharides hadan action of protection from CC14 -induced chemical liver injury.2. Effect of cordyceps polysaccharides on D-Gal-induced chemicl liver injury models.With the same dose and methods ( 150, 250, 500 mg kg-1, ig ) the experiment showed that cordyceps polysaccharides had the same protective effects on hepatic injury caused by D-Gal as it caused by CC14,which suggested cordyceps polysaccharides had an action of protection from D-Gal-induced chemical liver injury.3. Effect of cordyceps polysaccharides on BCG+LPS-induced immunological liver injury models.On the base of models of BCG+LPS-induced immunological liver injury, cordyceps polysaccharides ( 150, 250, 500 ing ' kg'', ig ) had the same protective effect on immunological hepatic injury as those caused by the above two drugs. It suggested cordyceps polysaccharides had an action of protect ion from BCG+LPS-induced immunological liver injury.4. Mechanisms of action of cordyceps polysaccharides on immunological liver injuryDifferent dose of cordyceps polysaccharides (150, 250,500 mg kg-1, ig) could significantly inhibited TNF-ccand IL-1 production in liver. It suggested that the protective action of cordyceps polysaccharides on immunological liver injury was possibly related to its equilibrum on cytokines production and modulation of immunological function.