Factors Affecting The Therapeutic Effects Of Cervical Erosion

IntroductionCervical erosion is a commonest pathologic change in chronic cervicitis, which has often been neglected for the deficiency of knowledge. It can not only cause clinical symptoms, but also develop into cervical intraepithelial neoplasia ( CIN) even cervical invasive carcinoma. The incidence of cervical carcinoma in patients with cervical erosion is 10 times higher than that in patients without this disease. Cervical erosion include mild, moderate, severe degree, CIN, and early stage of cervical invasive carcinoma. At present, the most commonly therapeutic methods for cervical erosion are physiotherapy and drug treatment, and loop electrosurgical excision procedure (LEEP) is more and more widely used in clinical work. In our study, we compared the therapeutic effects of microwave, CO2 laser, LEEP on cervical erosion and analyze the different factors involving cervical erosion and determine the appropriate treatment for different degrees of erosion.MethodsWe collected outpatients (I, 60 cases) , who were assigned randomly into microware group and CO2 laser group. The concretion of microwave was performed after menstruation 3 ~ 7 days after the examination for pathogenic microorganism, liquid - based cytology. The power of operation was 30 watt and the operative area went beyond normal tissue 2 mm, deep into cervical canal 2 mm to make it shallow cone. In the case of cyst we released the liquid and then boil off the wall of the cyst. As for CO2 laser group, the power of operation, wave-length, and diameter of diaphragm were 150 watt, 10.6(m, and 3mm, respectively. The range of treatment was the same as above. Moreover, we collected outpatients (II, III, 90, respectively) , who were divided randomly into three groups each-, microware group, C02 laser group and LEEP group. As far as LEEP group is concerned, the cutting depth of cervical canal and cervical tissues beside was 1.0 ~2. 0 cm, 0. 6 ~0. 8cm, respectively. The patients were followed -up in 2, 4-6, 8, 12 weeks after therapy to observe the discharge and colporrhagia, menstruation changing, conglutination or straitness of the cervical ora, infection, granulation hyperplasia, and so on, which were then compared with those of C02 laser group and LEEP group. All data analysis was assessed using X -test and P<0.05 was considered significant.ResultsThe first cure rate of I, II III was 74.4% , 71. 1% , 98. 3% , respectively. The cure rate of III in LEEP group was higher than microwave and C02 laser groups I erosion belonged mainly to simple type, whereas II and III were mostly granular erosions. The pathogen infection rate of I, II, III was 8. 3% , 14.4% , 13. 3% , respectively. Compared with cured patients, the infection rate of uncured was much higher. When the uncured time was 4 ~ 6 W, the infective type belonged mainly to mycotic infection. However, if the course was longer than 8W, trichomonal infection was mostly appeared. The average healing time of microwave and CO2 laser for II and III erosion was 8 - 12 W. As for LEEP, the average time was 6W.ConclusionThe healing time of LEEP was much shorter than those of microwave and C02 laser and the therapeutic rate was much higher. Infection is a main affecting factor of cure rate involving cervical erosion.