| Objective: To study the lipid-lowering effects of KDC-TT .Methods: We fed SD rats with rich-oil food for 21 days successively, meanwhile treating the animals by oral injection with KDC-TT,measured TC,TG,LDL-C ,HDL-C ,ApoAI , ApoB and LPO in the serum as well as TG and TC in the arterial wall and in the liver tissue. In another experiment, SD rats were fed with rich-oil food for 35 days, from the 22th day the animals were treated with KDC-TT by oral injection. TG,TC,LDL-C and HDL-C in the serum were measured to study the effects of the drug. At the same time, we fed the NIH mice with D-fructose to build acute hypertriglyceridemia model for studying the effect on decreasing TG in the serum.Results: KDC-TT significantly decreased the TC,TG and LDL-C levels in the serum of rats with hyperlipidemia . TG ,TC levels in the arterial wall and in the hepatic tissue declined. Atherosclerosis Index(AI) also declined. The concentration of Apo B decreased while HDL-C and ApoAI didn't changesignificantly. LPO in the plasma was inhibited by KDC-TT , SOD and GSH raised in the group with a dose of 300mg.kg-1. Treating the hyperlipidemia with KDC-TT after the rats were fed for 21 days with a rich-oil food, we observed that the level of TG in the serum fall to a lower one , the same with the levels of TC,LDL-C in the highest dose group. For the mice with an acute hypertriglyceridemia,KDC-TT also showed a strong effect on decreasing TG level in the serum.Conclusion: KDC-TT possesses the effects of decreasing TG,TC,LDL-C,lipid peroxide and ApoB in the serum , decreasing TG and TC in the liver and in the arterial wall of rats with hyperlipidemia induced by feeding rich-oil food ; it also has the effects of reducing TG levels in the serum of mice with acute hypertriglyceridemia. |
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