| Excimer laser in situ keratomileusis (LASIK) maintain integrity of the corneal epithelium and Bowman, so LASIK correspond to the corneal anatomicophysiology. It has been proven that the safety, stability and predictability of LASIK are better than those of photorefractive keratectomy(PRK) and autolaminate keratectomy(ALK). In past years refractive regression has been found after LASIK for treatment of high myopia and over-high myopia, regression can affect the role of treatment.Objectives: The purpose of this study was to evaluate the regression relevant factors of LASIK for treatment on high and over-high myopia during the 6 months post-operation.Methods: The prospective study involved 47 patients (93 eyes) with high and over-high myopia who received LASIK treatment. They were divided into two groups according to preoperative diopters (-6.OOD~-9.OOD in 59 eyes; -9.25D~-14.0D in 34 eyes). The follow-up time was 6 months, and the results of postoperative visual acuity, refractive diopter, corneal thickness and the ocular axis length were collected and analyzed by analysis of variance(ANOVA), chi-square test and multiple regression and vector analyses. P value was set on 0.05.Results: The results as following: In the group A, there were 5 eyes regressive operative eyes(8.47%); In the group B, there was 12 eyes regressive operative eyes(35.2%), the difference of regressive eyes between group A and group B was significant (x2=10.39, p<0.05). The cases with regression generally be found that the thickness of central corneal increased(82.4%), the change of the thickness of central corneal between regressive eyes group and normal group was significant. Both in group A and group B, the age, gender and ocular axis length were not related to regression.Conclusion: The preoperative refraction and the increasing of central comeal thickness were related to post-operation regression in contrast to age, gender and eye axis length. Further study for the longer time follow-up is necessary. |
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