Comparative Evaluation Of Surgical Stress Of Different Lymph Node Dissection For Gastric Cancer

Background: to objectively evaluate the surgical trauma of open surgery for gastric cancer with different lymph node dissectionMethods: altogether, 30 patients with gastric cancer were divided into three groups according to the range of lymph node dissection. Peripheral blood samples were obtained to measure serum interlukin-6, interleukin-8, C-reactive protein, and polymorphonuclear elastase. Additionally, peripheral leucocytes and lymphocytes count are included.Results: all the 3 groups caused a significant increase in serum IL-6, IL-8, CRP and polymophonuclear elastase (PMNE). There is no significant difference between D1 and D2 group. While the comparison between D3 and the other two groups showed significantly higher serum IL-6, IL-8, CRP and PMNE in D3 group. Leucocytes count shows no difference among 3 groups. After operation, the patients in 3 groups had a transient lymphocytes decrease. On the second and third postoperative days, the lymphocytes number in D3 group still decrease while those in Dl and D2 began to increase.Conclusion: Our study demonstrated that serum IL-6, IL-8, CRP and PMNE can be used to monitor surgical stress. By using these parameters, we found extended lymph node dissection in D3 group leads to more postoperative stress than Dl and D2 groups.