Clinical Study On The Relationship Between Interleukin-6,C-reactive Protein And Prognosis Of Patients With Thoracic Trauma

Objective:To explore the relationship between the dynamic changes of peripheral blood interleukin-6(IL-6)and C-reactive protein(CRP)levels and prognosis in patients with different degrees of thoracic trauma.Methods:Two hundred patients with thoracic trauma treated in our hospital from March2016 to January 2020 were divided into mild group(ISS score 1-2,n=81),severe group(ISS score 3,n=62)and critical group(ISS score 4-5,n=57)according to the injury severity scale(Injury severity score,ISS).According to the prognosis,the patients with thoracic trauma were divided into survival group(n=182)and death group(n=18).To analyze the difference of the expression of IL-6 and CRP in peripheral blood of patients with thoracic trauma under different severity and prognosis,and to analyze the diagnostic value of IL-6 and CRP in the prognosis of patients with thoracic trauma by ROC curve.Results:1 There was no significant difference in baseline data among all groups in terms of sex,age and type of trauma(P > 0.05).2 In the case of chest trauma with different severity,IL-6 and CRP in the critical group were significantly higher than those in the mild and severe groups on 1st day after trauma.3 On the 3rd day after trauma,the levels of IL-6 and CRP in peripheral blood of patients in the three groups were evidently higher than those in the 1st day after trauma(P < 0.05),and the levels of IL-6 and CRP in the critical group were obviously higher than those in the mild and severe groups4 On the 7th day after trauma,the peripheral blood IL-6,CRP levels were reduced to 3 days after trauma(P <0.05),and.the plasma IL-6 of patients with crisis group was significantly higher than the mild and severe group(P <0.05)5 The concentration of IL-6 and CRP in the 12 days after trauma in the three groups were evidently lower than those in the 7 days after trauma,and the CRP in the critical group was markedly higher than that in the mild and severe groups(P < 0.05),but there was no difference in the level of IL-6 among the three groups(P < 0.05).6 Gender,age,and traumatic,the three type of patients’ baseline conditions affect the survival situation has no evidently difference in patients(P> 0.05)7 Under different prognosis groups,the concentration of IL-6 and CRP in the death group were significantly higher than those in the survival group(P < 0.05).The(AUC)results of the area under the ROCcurve using the fluctuation of IL-6 and CRP expression to predict the death of chest trauma were higher than those of the reference line(P < 0.05).The cut-off value of IL-6 was 171.93 ng and the cut-off value of AUC was 7.59 mg.It was confirmed that the CRP of combined diagnosis was significantly higher than that of the reference line(P < 0.05),the sensitivity was 89.70%,and the specificity was 75.70%.Conclusion:The levels of IL-6 and CRP in peripheral blood from patients with chest trauma were closely related to their prognosis,but had no relationship to do with the sex,age and type of injury.The fluctuation of IL-6 and IL-6 in patients blood was only positively correlated with the severity of trauma.The results of 1d,3d,7d and 12 d after injury showed a trend of rising at first and then descending,which was of positive significance to the evaluation of patients’ prognosis,and the prediction effect was better by combined detection.