Studies Of The Therapeutic Actions Of QYW On Chronic Pharyngitis

QYW consists of Trichosanthis kirilowii Maxim, Fritillaria cirrhosa D. Don, Terminalia chebula Retz,Pueraria thomsonii Benth and so on. It can clear away heat to advantage the throat and promote the production of body fluid to quench thirst. Clinically it is used to cure chronic pharyngitis with low toxicity. In the present study, the anti-immune, anti-inflammatory, analgesic and apophlegmatic effects of QYW were investigated. The apophlegmatic and immune effects of each component of QYW were also approached by means of orthogonal design.In anti-inflammatory experiments, the ear edema induced by xylene and the increase in vascular permeability induced by acetic acid in mice were signifantly inhibited by QYW at the dose of 2-4g/kg(ig, same below). The hind paw edema induced by carrateenan in rats were markedly abated by QYW at the dose of l-2g/kg. It also showed the suppressive action to the proliferation of granuloma induced by cotton-pellet in mice.In immunological experiments, QYW at the dose of 1-4g/kg ig once a day for 7 days showed a significant immunosupression effect. It decreased the carbon clearance rate of charcoal particles, inhibited the production of the hemolysin immunized with SRBC and suppressed the delayed type hypersensitivity reaction induced by DNCB in mice. However it had no obvious effect on thymus index or spleen index.In analgesic experiments, It has been proved that QYW has analgesic actions in writhing induced by acetic acid and in the hot-plate test in mice.In addition, QYW obviously increased the excretion of phenol red in mice, supporting a strong apophlegmatic effect.The immune and apophlegmatic effects of each component of QYW were approached by means of orthogonal design. It was found that Glycyrrhiza uralensis Fisch, Trichosanthis kirilowii Maxim, Pueraria thomsonii Benth, Fritillaria cirrhosa D.Don, Poria cocos(Schw)W olf significantly inhibited ear swelling on DTH induced by DNCB in mice, however, baiyaojian and Terminalia chebula Retzhad no obvious effect, and Fructus mume(sieb)sieb. et zucc had negative effect. In apophlegmatic experiment, Fritillaria cirrhosa D.Don, Fructus mume(sieb)sieb. et zucc, Trichosanthis kirilowii Maxim, baiyaojian increased the excretion of phenol red in mice. A positive synergism on the excretion of phenol redwas observed when Trichosanthis kirilowii Maxim and Fructus mume(sieb)sieb. et zucc or Terminalia chebula Retz and Pueraria thomsonii Benth or Fritillaria cirrhosa D.Don and baiyaojian were used in combination.These results indicated that QYW could obviously inhibit immunization and markedly increase phlegm in mice. This study provides a theorical foundation to QYW on the treatment of chronic pharyngitis.