The Experimental And Clinical Study Of Administration Shahaosan In Socket

The most common complication in the healing of extraction wounds is dry socket, which may also be termed "fibrinolytic alveolitis". Reduction in the incidence of this condition after all kinds of applications has been reported. Shahaosan is a Chinese medicine which is made from Artemisia desertorum Spreng. The purposes of this study were to evaluate the use of Shahaosan as a prophylactic therapy for the prevention of dry socket. This study was divided into two parts.First, animal study. Purpose: A histological study of disturbed alveolar socket healing in dogs was carried out to analyze the influence of application of Shahaosan or Yunnanbaiyao. Methods: Eight dogs were divided into 4 groups of 2 animals each. The animal models were built by removing the second and third premolar of dogs. The animals were sacrificed 5, 7, 14 and 30 days after tooth extraction. The maxillas and associated soft tissues were dissected from each animal and fixed in 10% formalin, decalcified and embedded in paraffin. Sections were cut at 6 microns and stained with hematoxylin and eosin for histological examination. Results: Microscopic examination of the Shahaosan group at 5 days after extraction showed more inflammation reaction than that observed in the control group. The Shahaosan was absorbed at 14 days. There wereno differences between the Shahaosan group and the control group. While the Yunnan baiyao group show more inflammation reaction until 30 days after extraction. Conclusion: The socket healing with Shahaosan was not delayed. Shahaosan can be absorbed better.Second, clinical study. Objective: to evaluate whether use of shahaosan would decrease the incidence of dry socket with lower third molar extractions. Methods: The trial was a randomized, double-blind, controlled study conducted among 274 subjects, each of whom required oral surgery for the removal of a minimum of one impacted mandibular third molar. They were divided into three groups by randomly: I, II ,III. Shahaosan and Yunnan baiyao were made into A and B. Their appearance were same. I group use A, II group use B, III group use nothing. Results: I group had a dry socket of 1.09%, II group had 2.32%, III group had 8.33%. The difference was statistically significant between I group and III group(P<0.05). Means of PoSSe scores: I group 19.5778, II group 26.9865, III group 22.8060. At last, A: Shahaosan; B: Yunnan baiyao. Conclusion: The results of this study suggest that use of Shahaosan after lower third molar extraction decreases the dry socket rate. To some extent, the Shahaosan can advance the quality of life.