The Insulin Resistance After Traumatic Brain Injury In Rats

Part One The changes in blood glucose and insulin after traumatic brain injury in ratsObjective: To study the changes in blood glucose and insulin in rats after traumatic brain injury.Method: Base upon the Feeney's model, the blood glucose and insulin concentration of each injuried animal group were measured 1/2 hour before injury and 6,12,24,48,72,120 hours after injury.Results: The blood glucose concentration increased markedly in each injuried group after injury. The severer the trauma was, the faster the blood glucose increased and the higher the concentration peak reached. The blood insulin concentration increased markedly in medium and severe injuried group, but not in light injuried one. The severer the trauma was, the faster the blood insulin increased and the higher the concentration peak reached. Conclusion: The post-traumatic hyperglycemia is probably associated with the changes of the hormones which can raise or drop the insulin level and insulin resistance.