| In this study, Huang Lian Yi Wei Ling(HLYWL) teblet was used to treat Helicobacter pylori(HP) correlative chronic superficial gastritis (CSG) and its therapeutic mechanism was investigated in theoretic, experimental and clinical domains.This study revealed that retention of dampness-heat in the stomach and deficiency of stomach-qi were the important pathogenesis of CSG. According to this, the therapy of clearing away pathogenic dampness-heat, supplementing the stomach-qi and regulating the stomach was formulated. HLYWL, which was applied in our department of digestive internal medicine for long term, was researched in this study. From the systematically clinical observation of 80 cases with CSG, we detected that HLYWL could improve the clinical symtoms and mucosal inflammation, inhibit and kill HP effectively. The total curative effects of HLYWL on CSG was 88.0%, mucosal inflammation improving rates was 90.0%, which were significantly higher than those of the control group (treated with colloidal bismuth subcitrate capsules and farazolidone), p<0.05, respectively. The HP-eradicating rates of experimental group was 56.0%, while that of the control group was 60.0%, there was no significant difference between the two groups. Experimental study showed that HLYWL had the effect of inhibiting HP and improving immunity of body. It could also promote the repairment of gastric mucosa damage. After the treatment with HLYWL, the destruction of HP cell wall was observed with electron microscope. Experimental and clinical study showed that HLYWL had no toxic and side effect. |
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