| Viraus hepatitis,alcoholic hepatitis,drug hepatitis and other liverdiseases are frequently encountered diseases now in China and in theworld.Especial1y,The morbidity of virus hepatitis is increasing yearby year .All kinds of liver dieases can cause the same pathologicchange which is denaturation and mecrosis of liver cell--- liverlesion.So researching and developing new drug to treating liverlesion is very important.The compound prescription of Chinese medicinal herbs havesignificant therapeutic effect in respect of treating 1iverlesion .Finding the active ingredients in compound prescription andstudying by the method of pharma codynamics and toxicology on theinstruction of the theory of traditional Chinese medicine is moreimportant.This can help to approve the regular rule and effectmechanism of compound prescription, to make the pharmaceutistechnology more better and to make standard,safe,quality criterionwhich can accelerate the mordernized and international steps ofcompound prescription.The effective part in Picrorhiza compositae can treat liver lesion(damp-heat in the liver and gallbladder).It is extracted and refinefrom Picrorhiza and Paeonia.The chemica1 ingredients in thiseffective part are Picroside and Paeoniflorin .This paper elaboratethe symptoms,the etiology and pathogenesis of the liver lesion(damp-heat in the liver and gallbladder).The paper also elaborate thePrinciple of Picrorhiza compositae and the curing mechanisms. Inexperiment,the whole prescription and the single comonent inPicrorhiza compositae have been researched by the measures oftoxicoIogy and pharma codynamics,from which we can see that thelIgRiIop&i%k%WI%l2itxprescription has better effect than single component.Theexperimental conclusions prove that Picrohiza conpositae can lowertransaminase,enhance the excretion of gall,and treat fibrop1asticproliferation in liver.It is possible to be an new type traditionalChinese medicine for treating liver lesion. |
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