Related Studies On GAP Standard Evaluation Of Andrographis Paniculata Nees

Herba Andrographis , also known commonly as "Chuanxinlian" , is the aerial parts of' Andrograpriis pfinictiJutfi Neos. (AP), a member o1' the plant family Aawthcict'ric. It is recorded in the Chinese Phtirmucopocin, 2000 edition; in Traditional Chinese Medicine (TCM), AP is an important "cold properly" herb: it is used to rid the body of heat, as in fevers, and to dispel toxins from the body. Now, it is used for upper respiratory infections, fever, herpes, sore throat, and a variety of other chronic and infectious diseases. In Scandinavian countries and India, it is commonly used to prevent and treat common cold.GAP, Good Agriculture Practice of Medicinal Plants and Animals, is to guarantee and standardize the cultivation and production of the medicina material during the whole process; and to product the Chinese medicines (raw materials) with "verity" , "high quality" , "standard!/.at ion" , and "controllable" . The GAP research of AP is supported by the State Depart mem of Science and Technology, and the cultivation research base is selected in Guangdong province, embodying and conforming to the principie "originality of the Chinese medicine. Mostly, evaluating and warranting the qua I ities of AP is crucial in the progress of the research and cultivation. The establishment of GAP Standard Evaluation of AP carries great weight on the process of the research, and supplies the formulation of SOP (Standard Operational Procedure) data needed.During the research, the author investigated the three main cult ivation bases of AP, which are in Raoping, Zhanjiang, and Guangzhou, and the conclusion of the investiga! ion and evaluation of the environment and the qual it ies of water and soil shows that all of them are suitable for the AP' s cultivation.The contents of andrographolid and 14-deoxy-l1, 12-didohydroandro-grapho| ide contained in leaves of Androgrphis paniculata, were analy/ed by reverse; phase1IPLC. The result of the analyses indicated that the highest, contents of andrographolide and 14-deoxy-ll,12-diclehydroandrographolide were found in thetsamples cultivated in Zhanjiang and Raoping. The novel method of lll'I.C chromatographic fingerprints, showing much more complete and abundant information in the chromatographs, is applied in the analysis and evaluation of the AP from different sites, and results well. The accumulating process of the very two main active phytochemical diterpenoids, andrographolid and M-dcoxy-11,12-didehydroandro-grapholide, had been studied and analyxed, and the results conclude that the best harvest time is the florescence ,or earlier florescence of AP.The evaluation of the quality of the seeds of AP, including the germination trials, and so on, had been done.The analysis and evaluations of the effects of using different fertiIi/ers and pest i c i des are careful 1 y managed . The residual contents of heavy metal i rons and fertili/crs and pesticides are warranted under the safe limits.