A Clinical Study Of The Effect Of Radiofrequeney Treatment For Lung Cancer

Surgical operation has been the main way for treatment of lung cancer in the past. But for those who has missed the chance for operation, the conduction of other therapeutic procedure seemed to be less effective although radiotherapy and chemotherapy has long been practiced.The application of radiofrequency has brought about some brightness to these patient. At present radoifrequency treatment is still in its early stage of development, many mechanisms of radiofrequency are still unclear, but people have found that the relation of therapeutic effect and the serum level of CYRFA21-1, IL-2 and IL-2R concerns to the cell immunity and the prognosis SO the purpose of this study is to observe the short term therapeutic effect of radiofrequency treatment by means of observing the variations of the serum level of CYFRA21-1, IL-2 and IL-2R so as to provide the experimental basis for the application of radiofrequency treatment for lung cancer.Method: Eighty nine patients with lung cancer were divided into two groups:41 under went operational excision and 48 with radiofrequency treatment. Another 30 normal people were used as control group. The ages in three groups ranged from 45 to 67 years with an average about 46.5 years. Eighty nine serum samples of lung cancer were taken 1 day before treatment and lOdays, 20 days, 30 days after treatment.CYFRA21-1 expression level in serum samples was measured by radio immunoassay. IL-2 and IL-2R levels in serum samples were measured by ELISA and compared before and after treatment. At the same time, lung tissues of the patients with lung cancer after radio frequency treatment was obtained and observed under light microscope and electron microscope.Results: Serum CYFRA21-1 in patients with lung cancer was 13.26?.74ug/L before operation and 3.22?.62ug/L after operation. It decreased remarkably after operation (p<0.05).Serum CYFRA 21-1 expression level in patients with lung cancer was 13.05 ?7.26ug/L before radiofrequency treatment. The decrease was not remarkably 10 days after radiofrequency treatment (p>0.05), but it was remarkably 20 days after radiofrequency treatment (p<0.05) and almost returned to normal level, although not so remarkable as that in operation group. The difference between radiofreqnency group and operation group was not significant 30 days after treatment (p>0.05), and so was the difference between radiofrequency group and normal control group(p>0.05). Serum IL-2 expression level increased remarkably after radiofrequency treatment (p<0.05)and SIL-2R decreased remarkably (P<0.05).A11 these indicate that radiofrequency can destroy the cancer mass effectively and improve the depressed cell immunity and stimulate the immunological activity of body cells.Conclusions: 1. The effect of radiofrequency treatment is definite and radiofrequency can destroy the tumor mass; 2. Radiofrequency is easy to do with minimal trauma, less pain and rapid recovery, it is especially effective for the lung cancer of late stage with metastasis; 3. Radiofrequency can improve the depressed cell immunity and stimulate the immunity of normal body cells.